COVID-19 – Infection Prevention and Control literature – May to July 2021

Selected papers that related to COVID-19 infection prevention and control from the daily COVID-19 Critical Intelligence Unit  listings and other identified literature.  This posting does not assess the specific evidence or its quality. Please let me know of any gaps – @mdjkf.

Evidence summaries from the IPC Panel of the Australian National COVID19 Evidence Taskforce on respirators, masks and eye protection  published here in May 2021 on MagicApp.  Updated continuously.

Peer reviewed

  • Wilson et al. JHI.  What is the evidence that medical procedures which induce coughing or involve respiratory suctioning are associated with increased generation of aerosols and risk of SARS-CoV-2 infection? A rapid systematic review. “There was an absence of evidence to suggest that the procedures included in the review were associated with an increased risk of transmission of respiratory infection.”

  • Deol et al, PLOS ONE. Estimating ventilation rates in rooms with varying occupancy levels: Relevance for reducing transmission risk of airborne pathogens . “..demonstrate two methods that can be used to estimate ventilation rate in busy congregate settings, such as clinic waiting rooms.”

  • Gregson et al, Endoscopy. Identification of the source events for aerosol generation during oesophago-gastro-duodenoscopy. “Coughing was evoked in 60% of the endoscopies, with a greater peak concentration and a greater total number of sampled particles than the patient’s reference voluntary coughs (11 710 vs 2320 L−1 and 780 vs 191 particles, n=9 and p=0.008). Endoscopies with coughs generated a higher level of aerosol than tidal breathing, whereas those without coughs were not different to the background. “

Preprints

  • Deng et al medRxiv. Viral infection and transmission in a large well-traced outbreak caused by the Delta SARS-CoV-2 variant. “…first local transmission of the Delta SARS-CoV-2 variant in mainland China. All 167 infections could be traced back to the first index case.” Relevant to the current NSW situation; high presymptomatic viral loads and transmission’ 1000-fold higher viral loads seen than previous strain
  • Wang et al. medRxiv. Comparative evaluation of the transmissibility of SARS-CoV-2 variants of concern.  
  • Ferris et al. Authorea.  FFP3 respirators protect healthcare workers against infection with SARS-CoV-2 . Important observational evidence from Cambridge in the setting of rampant spread of B.1.1.7 (Alpha variant).  “After the change in respiratory protection, cases attributed to ward-based exposure fell significantly, with FFP3 respirators providing 31-100% protection (and most likely 100%) against infection from patients with COVID-19.”
  • Grout et al. MJA. Estimating the failure risk of quarantine systems for preventing COVID-19 outbreaks in Australia and New Zealand . Good lessons from this analysis!

  • Coleman et al. medRxiv. Viral Load of SARS-CoV-2 in Respiratory Aerosols Emitted by COVID-19 Patients while Breathing, Talking, and Singing.  The largest proportion of SARS-CoV-2 RNA copies was emitted by singing (53%), followed by talking (41%) and breathing (6%). Overall, fine aerosols constituted 85% of the viral load detected in our study. Virus cultures were negative. Singapore 2021 data ; most patients had VOC infections though only one with Delta. 

Commentaries

  • Wark et al MJA. We are not doing enough to prevent the spread of COVID-19 and other respiratory viruses in Australian hospitals.
  • McMorrow CDC (USA). Improving communications around vaccine breakthrough and vaccine effectiveness.  USA vaccine efficacy evidence in setting of Alpha and Delta variants. “Risk of severe disease or death reduced 10-fold or greater in vaccinated and Risk of infection reduced 3-fold in vaccinated.”
  • Wei et al. JAMA.  Nine Lessons Learned From the COVID-19 Pandemic for Improving Hospital Care and Health Care Delivery. Wisdom from New York’s experience.
  • Hyde et al. MJA. Australia must act to prevent airborne transmission of SARS‐CoV‐2.

About mdjkf

Microbiologist and Infectious Diseases Physician
This entry was posted in Module-virology and tagged , . Bookmark the permalink.

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