Invasive pneumococcal disease – the impetus for immunisation

Invasive Pneumococcal Disease Surveillance (Australia) recent report gives you a good idea of which serotypes of pneumococcus are within the different vaccines and the recent changes to serotype-specific IPD indidence – we are seeing quite an impact that is focused on serotypes within the vaccine. Some evidence of non-vaccine serotype escape in recent years.  Figure–  Australian IPD notifications 2002-2016.

Australian Indigenous rates (age > 50 yrs) (Figure 3 in above report) remain much higher than comparable data for non-indigenous adults (> 65 yrs) (Figure 4).

Australian childhood rates dropped in 2011 coincident with implementation of the 7vPCV – currently around 250-300 childhood events per annum.   Contrast this to an estimate from PNG that approximately 826,000 children, mostly young infants, die annually from invasive pneumococcal disease provided in this important recent 7vPCV RCT in PNG which examined safety and immunogenicity of neonatal pneumococcal conjugate vaccination in children.  Implementation of neonatal and childhood pneumococcal vaccination is one of the  highest priority issues for PNG.

About mdjkf

Microbiologist and Infectious Diseases Physician
This entry was posted in Bacteria (GPOS), Module-Respiratory infections, Public health and tagged , . Bookmark the permalink.

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