Adenovirus overview -2016-path-north; Prepared for our weekly pathology teaching round by one of our registrars.
Reference
Image credit: http://www.daviddarling.info/encyclopedia/A/adenovirus_infection.html
Guest posting from our Infectious Diseases advanced trainee, Dr Milton Micallef.
N.B.
Guest posting: A/Prof Josh Davis, Infectious Diseases Physician, John Hunter Hospital, NSW, Principal Research Fellow, Menzies School of Health Research, NT, Australia.
Another excellent presentation from Josh. HEV talk ASID Annual Scientific Meeting 2016_Davis. An essential topic for ID and Pathology post-grads!
References (both free text)
Guest posting: Dr Ayesha Akram, Microbiology Registrar, Pathology North, NSW.
Prematurity and low birth weight are important causes of neonatal death and despite increasing awareness of the importance of these adverse pregnancy outcomes, the causes remains unknown on many occasions. Dengue fever is endemic in many regions of the world especially in Southeast Asia and Oceania. With 390 million estimated dengue infections each year woman of reproductive age are also at increasing risk of symptomatic dengue infection. Previously very little was known about the possible adverse effects of dengue infection during pregnancy. Continue reading
Excellent overview by the Australian expert, Stephen Graves that is highly relevant to all countries, not just Australia. Professor Graves has been responsible for ground-breaking discoveries in this area and has much wisdom to impart. The incidence of rickettsial disease and Q fever in many tropical locations is poorly studied.
Laboratory assays for diagnosis of tick-borne infections- Graves June 2016
It’s important to understand as much as you can about Staphylococcus aureus – it is such a prevalent cause of community and healthcare-associated infection and remains a major challenge to control. It’s not just one species – various clones of MSSA and MRSA dominate across parts of the world and within subpopulations for reasons that are not always apparent despite much deep research into organism sequences and putative virulence gene expression. Always important to keep in mind that the epidemiology of S. aureus will vary in different locations according to what specific strains are prevalent. Critical host factors that make disease more likely are also still in dispute – watch this space! Continue reading
Here is an example comment from Pathology North which is added to positive blood culture reports when a Gram negative coliform species ( Enterobacteriacae eg. E. coli) has been isolated:
The comment’s rationale is to promote short course treatment and also to prompt oral antibiotic switching in a timely manner. It also prompts consideration of source control, an important issue in all patients with sepsis. There are no data that establish a minimum duration for IV therapy. Endocarditis and other metastatic complications are extremely rare with these species, contrasting with bacteraemia due to Staphylococcus aureus where prolonged high dose IV therapy is predicated on this risk.
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Very good clinicopathological presentation of fatal meningococcal sepsis.
This unfortunate 27 year old pregnant woman collapsed at home with a seizure and then died soon after. She had a disseminated W135 serotype infection – this serotype has been associated with a number of recent severe cases in Hunter New England. Neisseria meningitidis case presentation Dr Rexson Tse May 2016
Perhaps there were no preventable features in this case, however useful to remember some key issues:
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Microbiology and Infectious Diseases postgraduate teaching (PRIDA) 